Uracil analogues of the acyclonucleoside 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]- methyl]guanine (BIOLF-62)
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چکیده
منابع مشابه
Synthesis of 1-Hydroxy-2-(Prop-2'-Enyl) 9-Antrone
An efficient synthesis of the 1-hydroxy-2-(prop-2'-enyl)9-anthrone is described. Selective nitration of anthraquinone, reduction to the corresponding amine, diazotization and treatment by sulfuric acid solution afforded the 1-hydroxy-9,10-anthraquinone in good yield as the key intermediate. Reaction with allyl bromide/K2CO3 and subsequent selective reduction accompanie...
متن کاملTHE SYNTHESES OF 1- [[2- AMINO -1 - (HYDROXYMETHYL) ETHOXY] METHYL] URACIL AND 1, 3-BIS (2- HALOETHOXYMETHYL) PYRIMIDINE
The syntheses of the title compounds are described. 1- [[2- Amino -1 - (hydroxymethyl) ethoxy] methyl] uracil exhibitslittleactivity against herpesviruses (HSV) in vivo
متن کاملSynergism among BIOLF-62, phosphonoformate, and other antiherpetic compounds.
9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine (BIOLF-62) is highly synergistic with either phosphonoformate or phosphonoacetate when used in combination against herpes simplex virus types 1 and 2 in vitro. Acycloguanosine did not show significant synergism with these two compounds. Bromovinyldeoxyuridine and phosphonoformate were highly synergistic against herpes simplex virus type 2, bu...
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The reaction o f N.N'-dim ethylurea with l,5-dim ethyl-2,4-bis-(dim ethylam ino)-l,5-diaza-2,4-dibora-3-oxacyclohexan-6-one (2) in the melt proceeds with condensation of the urea to yield two major products: the acid l,3,5-trim ethyl-2-hydroxy-l,3,5-triaza-2-boracyclohexa-4,5-dione (la); and a mixture of the methylammonium (4a) and dimethylammonium salt (4b) of the anion [{C H 3N («-C O N C H 3...
متن کاملConversion of the Oncogenic 1-Methylguanine 3-Oxide to 3-Hydroxy-1-methylxanthine1
tion of 1-methylguanine 3-oxide was not observed (8). This observation, combined with the very low activity of 1-meth ylguanine 3-oxide as a substrate for sulfotransferase in an in vitro assay for activation (10), caused us to compare the metabolic fates of 1-methylguanine 3-oxide and 3-hydroxy 1-methylxanthine with their unmethylated parent 3-hydroxy purines to provide a better understanding o...
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ژورنال
عنوان ژورنال: Canadian Journal of Chemistry
سال: 1984
ISSN: 0008-4042,1480-3291
DOI: 10.1139/v84-004